2020 (Vorarbeit)

Relja B, Huber-Lang M, van Griensven M, Hildebrand F, Maegele M, Nienaber U, Brucker DP, Sturm R, Marzi I. A nationwide fluidics biobank of polytraumatized patients: implemented by the Network "Trauma Research" (NTF) as an expansion to the TraumaRegister DGU ® of the German Trauma Society (DGU). Eur J Trauma Emerg Surg. 2020; 46(3): 499-504. doi: 10.1007/s00068-019-01193-3. 

2022

Lupu L, Horst K, Greven J, Mert Ü, Ludviksen JAK, Pettersen K, Lau C, Li Y, Palmer A, Qin K, Zhang X, Mayer B, van Griensven M, Huber-Lang M, Hildebrand F, Mollnes TE. Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma. Front Immunol. 2022 Aug 18;13:952267. doi: 10.3389/fimmu.2022.952267.

Weber, B.; Franz, N.; Marzi, I.; Henrich, D.; Leppik, L. Extracellular vesicles as mediators and markers of acute organ injury: current concepts. Eur J Trauma Emerg Surg 2022, 1–20, doi:10.1007/s00068-021-01607-1.

Gröger M, Hogg M, Abdelsalam E, Kress S, Hoffmann A, Stahl B, Calzia E, Wachter U, Vogt JA, Wang R, Merz T, Radermacher P, McCook O. Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1. Front Med (Lausanne). 2022 Apr 29;9:878823. doi: 10.3389/fmed.2022.878823. PMID: 35572988; PMCID: PMC9106371.

2023

Fachet M, Mushunuri RV, Bergmann CB, Marzi I, Hoeschen C, Relja B. Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma. Front Immunol. 2023 Dec 12;14:1281674. doi: 10.3389/fimmu.2023.1281674. eCollection 2023. PMID: 38193076

Weber, B.; Henrich, D.; Hildebrand, F.; Marzi, I.; Leppik, L. THE ROLES OF EXTRACELLULAR VESICLES IN SEPSIS AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME. Shock 2023, 59, 161–172, doi:10.1097/SHK.0000000000002010.

Haussner F, Maitz A, Rasche V, Hoffmann A, Braumüller S, Lupu L, Ignatius A, Neff TA, Palmer A, Huber-Lang M. Intestinal damage and immune response after experimental blunt abdominal trauma. Shock. 2023 Dec 1;60(6):784. doi: 10.1097/SHK.0000000000002302. PMID: 38153806 

Weber, B.; Henrich, D.; Schindler, C.R.; Marzi, I.; Leppik, L. Release of exosomes in polytraumatized patients: The injury pattern is reflected by the surface epitopes. Front. Immunol. 2023, 14, 1174, doi:10.3389/fimmu.2023.1107150.

Groven RVM, Greven J, Mert Ü, Horst K, Zhao Q, Blokhuis TJ, Huber-Lang M, Hildebrand F, van Griensven M. Circulating miRNA expression in extracellular vesicles is associated with specific injuries after multiple trauma and surgical invasiveness. Front Immunol. 2023; 14: 1273612. doi: 10.3389/fimmu.2023.1273612

Weber, B.; Sturm, R.; Henrich, D.; Lupu, L.; Rottluff, K.; Marzi, I.; Leppik, L. Diagnostic and Prognostic Potential of Exosomal Cytokines IL-6 and IL-10 in Polytrauma Patients. Int. J. Mol. Sci. 2023, 24, doi:10.3390/ijms241411830.

Weber, B.; Sturm, R.; Henrich, D.; Marzi, I.; Leppik, L. CD44+ and CD31+ extracellular vesicles (EVs) are significantly reduced in polytraumatized patients with hemorrhagic shock - evaluation of their diagnostic and prognostic potential. Front. Immunol. 2023, 14, 1196241, doi:10.3389/fimmu.2023.1196241.

2024

Barth H, Worek F, Steinritz D, Papatheodorou P, Huber-Lang M. Trauma-toxicology: concepts, causes, complications. Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2935-2948. doi: 10.1007/s00210-023-02845-3

Weber, B.; Ritter, A.; Han, J.; Schaible, I.; Sturm, R.; Relja, B.; Huber-Lang, M.; Hildebrand, F.; Pallas, C.; Widera, M.; et al. Development of a Sampling and Storage Protocol of Extracellular Vesicles (EVs)-Establishment of the First EV Biobank for Polytraumatized Patients. Int. J. Mol. Sci. 2024, 25, doi:10.3390/ijms25115645.

Becker N, Franz N, Eguchi A, Wagner A, Sturm R, Rinderknecht H, Kobayashi Y, Iwasa M, Weber B, Marzi I, Relja B. Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma. Front Immunol. 2024 Jun 12;15:1390380. doi: 10.3389/fimmu.2024.1390380. eCollection 2024. PMID: 38933277

Feth M, Hezel F, Gröger M, Hogg M, Zink F, Kress S, Hoffmann A, Calzia E, Wachter U, Radermacher P, Merz T. Metabolic Effects of Sodium Thiosulfate During Resuscitation from Trauma and Hemorrhage in Cigarette-Smoke-Exposed Cystathionine-γ-Lyase Knockout Mice. Biomedicines. 2024 Nov 12;12(11):2581. doi: 10.3390/biomedicines12112581.

Hörauf JA, Schindler CR, Schaible I, Wang M, Weber B, El Saman A, Pallas C, Widera M, Marzi I,Henrich D, Leppik L. Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury. Front Immunol. 2024 Nov 27;15:1478786. doi: 10.3389/fimmu.2024.1478786. PMID: 39703513; PMCID: PMC11656158.

Li Y, Horst K, Greven J, Mert Ü, Lupu L, Palmer A, Doerfer L, Zhao Q, Zhang X, Halbgebauer R, Ignatius A, Marzi I, van Griensven M, Balmayor E, Hildebrand F, Mollnes TE, Huber-Lang M. Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model. Front Immunol. 2024 Nov 21;15:1434274. doi: 10.3389/fimmu.2024.1434274.

Ritter, A.; Han, J.; Bianconi, S.; Henrich, D.; Marzi, I.; Leppik, L.; Weber, B. The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury. Int. J. Mol. Sci. 2024, 25, doi:10.3390/ijms252011282.

Ritter, A.; Lötterle, L.; Han, J.; Kalbitz, M.; Henrich, D.; Marzi, I.; Leppik, L.; Weber, B. Evaluation of New Cardiac Damage Biomarkers in Polytrauma: GDF-15, HFABP and uPAR for Predicting Patient Outcomes. Journal of clinical medicine 2024, 13, doi:10.3390/jcm13040961.

Schindler CR, Hörauf JA, Weber B, Schaible I, Marzi I, Henrich D, Leppik L. Identification of novel blood-based extracellular vesicles biomarker candidates with potential specificity for traumatic brain injury in polytrauma patients. Front Immunol. 2024 Mar 12;15:1347767. doi: 10.3389/fimmu.2024.1347767. PMID: 38533491; PMCID: PMC10963595.

Weber, B.; Henrich, D.; Marzi, I.; Leppik, L. Decrease of exosomal miR-21-5p and the increase of CD62p+ exosomes are associated with the development of sepsis in polytraumatized patients. Molecular and cellular probes 2024, 74, 101954, doi:10.1016/j.mcp.2024.101954.

Rald VM Groven, Christel Kuik, Johannes Greven, Ümit Mert, Freek G Bouwman, Martijn Poeze, Taco J Blokhuis, Frank Hildebrand, Berta Cillero-Pastor, Martijn van Griensven. Fracture hematoma proteomics. Bone and Joint Research. 2024; 13(5): 214-225. DOI: 10.1302/2046-3758.135.BJR-2023-0323.R1

Nan Zhou, Rald VM Groven, Klemens Horst, Ümit Mert, Johannes Greven, Tom Eirik Mollnes, Markus Huber-Lang, Martijn van Griensven, Frank Hildebrand, Elizabeth R. Balmayor. Pulmonary miRNA expression after polytrauma depends on the surgical invasiveness and displays an anti-inflammatory pattern by the combined inhibition of C5 and CD14. Front. Immunol. 2024; 15: 1402571. DOI: 10.3389/fimmu.2024.1402571

Ümit Mert, Rald VM Groven, Johannes Greven, Zhizhen He, Mohamad Agha Mahmoud, Martijn van Griensven, Markus Huber-Lang, Tom Eirik Mollnes, Elizabeth Rosado Balmayor, Klemens Horst, Frank Hildebrand. Damage Control Orthopaedics Induced Less Trauma-Induced Coagulopathy than Early Total Care in a Porcine Polytrauma Model. Eur. Surg. Res. 2024; 65 (1): 115-22. DOI: 10.1159/000541399

2025

Groven RVM, Mert Ü, Greven J, Horst K, Joris V, Bini L, Poeze M, Blokhuis TJ, Huber-Lang M, Hildebrand F, van Griensven M. Early total care and damage control orthopaedics result in partially contrasting patterns of microRNA expression at the fracture site and in the systemic circulation : an animal study. Bone Joint J. 2025; 107 (2): 193-203. doi: 10.1302/0301-620X.107B2.BJJ-2024-0160.R3.

Han, J.; Leppik, L.; Sztulman, L.; Rosa, R. de; Pfeiffer, V.; Busse, L.-C.; Kontaxi, E.; Adam, E.; Henrich, D.; Marzi, I.; et al. Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiomyocyte Damage. Cells 2025, 14, 300, doi:10.3390/cells14040300.

Sturm R, Haag F, Bergmann CB, Marzi I, Relja B. Alcohol drinking leads to sex-dependent differentiation of T cells. Eur J Trauma Emerg Surg. 2025 Jan 27;51(1):87. doi: 10.1007/s00068-024-02732-3. PMID: 39870931

Weber B, Welz W, Schaible I, Han J, Henrich D, Marzi I, Leppik L. Influence of hemolysis, lipemia and bilirubin on biobank sample quality – origin and interference in the use for extracellular vesicle (EV) and miRNA analyses. Eur J Trauma Emerg Surg. 2025 Mar 26;51(1):153. doi: 10.1007/s00068-025-02822-w.

Hörauf JA, Singh A, Voth M, Moheimani H, Schindler CR, Relja B, Leppik L, Marzi I, Henrich D. Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker. Diagnostics (Basel). 2025 Jan 14;15(2):179. doi: 10.3390/diagnostics15020179. PMID: 39857063

Leppik L, Manamayil M, Schindler C, Sturm R, Störmann P, Henrich D, Marzi I, Weber B. New role for an old acquaintance: miR-1246 as a new inflammatory and prognostic marker in polytrauma patients. PeerJ. 2025 Apr 7;13:e19185. doi: 10.7717/peerj.19185. PMID: 40212366; PMCID: PMC11984479.

Hörauf JA, Leppik L, Weber B, Hildebrand F, Störmann P, Henrich D, Marzi I, Schindler CR. MiR338-3p expression in extracellular vesicles after severe trauma with or without traumatic brain injury. Brain Commun. 2025 Jun 21;7(4):fcaf242. doi: 10.1093/braincomms/fcaf242. PMID: 40666703; PMCID: PMC12261298.

Wang T, Alalman O, Wagner A, Bülow JM, Rinderknecht H, Relja B. A20 modulates ethanol-induced suppression of NF-κB-mediated hepatic inflammation in in vitro polytrauma conditions. Shock. 2025. Suppl. Issue Sept.

Becker N, Bülow JM, Wagner A, Eguchi A, Rinderknecht H, Relja B. Early sepsis risk assessment in multiple trauma patients using the sepsis as trauma outcome prediction (stop) score – a prognostic accuracy of 59.4% within 24 hours post-emergency department admission. Shock. 2025. Suppl. Issue Sept.

Bülow JM, Vo MT, Wagner A, Rinderknecht H, Relja B. Alcohol-dependent regulation of energy metabolism by NF-κB signaling in HepG2 cells. Shock. 2025. Suppl. Issue Sept.

Herminghaus A, Totskyi M, Vollmer C, Dimski T, Brandenburger T, Kuebart A, Rinderknecht H, Bergmann CB, Vernikouskaya I, Bülow JM, Becker N, Relja B. Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis. Front Immunol. 2025 May 29;16:1591262. doi: 10.3389/fimmu.2025.1591262. PMID: 40510342

SturmR, Haag F, RinderknechtH, BülowJM, Wagner N , ZabelJ, Bergmann CB, Marzi I, Relja B. Granulocyte function in response to acute alcohol consumption: temporal shifts from proinflammatory activation to antiinflammatory modulation in healthy volunteers. J Leukoc Biol. 2025 Jun 4;117(6):qiaf081. doi: 10.1093/jleuko/qiaf081. PMID: 40479504

Bülow JM, Rinderknecht H, Becker N, Köhler K, Wagner A, Yang Y, Bundkirchen K, Neunaber C, Relja B. Exploring the Bone-Liver Axis: Impact of Acute Ethanol Intoxication on Post-Traumatic Liver Inflammation and Damage Following Femur Fracture. Int J Mol Sci. 2025 May 21;26(10):4923. doi: 10.3390/ijms26104923. PMID: 40430063

Becker N, Bülow JM, Franz N, Marzi I, Gebhard F, Eguchi A, Rinderknecht H, Relja B. Assessment of early indicators for sepsis development in multiple trauma patients - the Sepsis as Trauma Outcome Prediction (STOP) score. Shock. 2025 May 14;64(2):187–197. doi: 10.1097/SHK.0000000000002626. PMID: 40367515

Reichardt LM, Hindelang B, Süberkrüb L, Hamberger KL, Graw JA, Schuetze K, Zechendorf E, Mannes M, Halbgebauer R, Wohlgemuth L, Gebhard F, Huber-Lang M, Relja B, Bergmann CB. Absolute lymphocyte count trajectory predicts clinical outcome in severely injured patients. Eur J Trauma Emerg Surg. 2025 May 2;51(1):190. doi: 10.1007/s00068-025-02864-0. PMID: 40314767

Jooss T, Maier K, Reichardt LM, Hindelang B, Süberkrüb L, Hamberger KL, Bülow JM, Schuetze K, Gebhard F, Mannes M, Halbgebauer R, Wohlgemuth L, Huber-Lang M, Relja B, Bergmann CB. Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients. Front Immunol. 2025 Mar 24;16:1538516. doi: 10.3389/fimmu.2025.1538516. PMID: 40196124

Sturm R, Haag F, Bergmann CB, Marzi I,Relja B. Alcohol drinking leads to sex-dependent differentiation of T cells. Eur J Trauma Emerg Surg. 2025 Jan 27;51(1):87. doi: 10.1007/s00068-024-02732-3. PMID: 39870931

Feth M, Gracco M, Gröger M, Hogg M, Kress S, Hoffmann A, Calzia E, Wachter U, Radermacher P, Merz T. Sodium thiosulfate does not affect energy metabolism or organ (dys)function during resuscitation from murine trauma-and-hemorrhage. Intensive Care Med Exp. 2025 Aug 6;13(1):80. doi: 10.1186/s40635-025-00778-0. PMID: 40768004; PMCID: PMC12328856.

Sztulman L, Ritter A, de Rosa R, Pfeiffer V, Draheim L, Leppik L, Busse L-C, Kontaxi E, Verboket R, Adam E, Marzi I, Weber B. Cardiac damage after polytrauma: The role of systematic transthoracic echocardiography - A Pilot Study. World J Emerg Surg. 2025 Mar 11;20(1):21.doi: 10.1186/s13017-025-00596-5